01NMN
GRADE BPromisingA direct precursor to NAD+, a coenzyme central to cellular energy and repair whose levels fall with age.
Studied dose 250–2,000 mg/day
Best longevity supplements, ranked by evidence
Compounds sold over the counter — NMN, NAD+ precursors, spermidine, taurine — ranked by human-trial evidence, not marketing. Where the evidence is thin, the page says so instead of filling the gap with mouse studies.
Ranked by: strength of human evidence — grade A first, D last. Never by commission.
02Spermidine
GRADE BPromisingA naturally occurring polyamine found in wheat germ, aged cheese, mushrooms and soy, studied as an oral supplement for its role in autophagy — the cell's internal recycling process, which declines with age.
Studied dose 1.2 mg/day
03Taurine
GRADE CEarlyA sulphur-containing amino acid the body makes and also obtains from food, present in high concentrations in muscle, heart and retina.
Studied dose 1–6 g/day
Guides
In-depth comparisons and rankings
The best longevity supplements, ranked by human evidence
Most longevity supplements are graded on mouse data. Here is the same shelf ranked only on human clinical trials — and what almost nothing on it has proven.
Read the guide →Best longevity supplements for cellular health and repair
Ranked on human trials only: which supplements have actually moved a cellular-repair marker in people — mitochondria, autophagy, NAD⁺, oxidative stress — and which are still mouse data.
Read the guide →What are the best science-backed longevity supplements?
'Science-backed' is the most abused phrase in supplements. Here is what it should mean, the five-question test, and the short list that actually passes on human trials.
Read the guide →What are the best clinically proven longevity supplements?
Proven for what, in whom, at what dose? Every longevity supplement with a completed randomised trial on a clinical endpoint — and the exact claim each trial supports.
Read the guide →Best longevity supplements stack for men over forty.
A three-item core stack with human trial evidence for men over forty — creatine, omega-3, conditional vitamin D — plus what to test first, what is optional, and the men's-health products to skip.
Read the guide →Which science-backed supplements can safely extend life?
Supplements ranked on both human evidence and safety for genuine life-extension claims: vitamin D correction, omega-3 in specific groups, creatine, fibre, and a short honest list of what does not qualify — with why almost nothing marketed as a longevity supplement meets both bars at once.
Read the guide →Best anti aging supplements to extend life naturally.
Anti-aging supplements ranked on human evidence for extending life or healthspan naturally: correcting vitamin D and B12 deficiency, omega-3 in specific groups, creatine, collagen for skin, and a clear-eyed look at NMN, resveratrol and other popular 'natural' anti-aging supplements with weak human evidence.
Read the guide →Complete supplement stack designed to extend lifespan effectively.
A supplement stack built strictly from items with genuine human evidence for extending lifespan or supporting healthy ageing: correcting deficiencies, omega-3 in specific groups, creatine, fibre, and protein — with why a shorter, evidence-based stack is more effective than a longer, comprehensive-sounding one.
Read the guide →Senolytic supplements and drugs: what actually has human data
Fisetin, quercetin, dasatinib: which senolytics have real human trial evidence, what those trials actually measured, and what's still just a mechanism story.
Read the guide →NMN vs NR: which NAD⁺ precursor has the better evidence?
Both raise NAD+ in humans and no trial has compared them head-to-head. What separates them is trial outcomes, safety history and where each is legal to buy.
Read the guide →The Longevity Brief
One evidence-graded email a week: what is new in longevity research, what is hype, and the one change actually worth making.
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