01Rapamycin
GRADE CEarlyAn mTOR-inhibiting drug approved for preventing organ-transplant rejection and treating a rare lung disease, taken off-label at low intermittent doses in the hope of slowing aging.
Studied dose 5–10 mg once weekly
Best longevity therapies, ranked by evidence
Prescription and supervised routes — GLP-1 medications, rapamycin, metformin, hormone protocols — ranked by human evidence. Approved uses, off-label reality, side effects and cost.
Ranked by: strength of human evidence — grade A first, D last. Never by commission.
02Metformin
GRADE CEarlyA first-line prescription medication for type 2 diabetes, of interest for longevity because of an observational finding that metformin-treated diabetics survived longer than non-diabetic controls.
Studied dose 500–2,000 mg/day, in divided doses
Guides
In-depth comparisons and rankings
Mounjaro vs Ozempic: which works better, and what it costs you
Tirzepatide beats semaglutide for weight loss in pooled data — but the evidence is weaker than the headlines suggest. Side effects, cost and who each suits.
Read the guide →Weight-loss peptides compared: semaglutide, tirzepatide, retatrutide and CagriSema ranked by evidence
Semaglutide, tirzepatide, retatrutide and CagriSema ranked by real trial data — including which ones are actually approved and which are still years away.
Read the guide →Which regenerative medicine treatments work best for joint pain?
Regenerative treatments for joint pain ranked against what actually works: exercise therapy and weight loss, GLP-1 agonists for knee OA, corticosteroid and hyaluronic-acid injections, PRP, bone-marrow and adipose stem-cell injections, autologous chondrocyte implantation, exosomes and clinic 'stem cells' — with a pharmacist's advice on what to try first.
Read the guide →What is the most effective regenerative medicine for knees?
Knee treatments ranked on randomised evidence — exercise, weight loss and semaglutide, MACI for cartilage defects, steroid, PRP, hyaluronic acid, bone-marrow and adipose cell injections, exosomes — separated by what is wrong with the knee: osteoarthritis, a cartilage defect, a meniscal tear or a ligament injury.
Read the guide →Which regenerative medicine options help avoid joint replacement?
Options for delaying or avoiding joint replacement ranked on evidence: exercise and weight loss, GLP-1 agonists, bracing and offloading, osteotomy, MACI for cartilage defects, steroid and PRP injections, stem-cell injections, exosomes — and when delaying a replacement does more harm than the operation.
Read the guide →What regenerative medicine is best for chronic back pain?
Chronic back pain treatments ranked on randomised evidence: exercise and cognitive-behavioural approaches, multidisciplinary rehabilitation, staying active, epidural and facet injections, radiofrequency ablation, intradiscal PRP and cell injections, basivertebral nerve ablation, spinal fusion — and the regenerative injections that have not beaten placebo.
Read the guide →Which regenerative medicine therapy is safest for arthritis patients?
Arthritis therapies ranked on safety for the arthritis patient: exercise and weight loss, topical NSAIDs, PRP, hyaluronic acid, corticosteroid injections, MACI, GLP-1 agonists, oral NSAIDs, bone-marrow and adipose cell injections, exosomes and clinic 'stem cells' — with the documented harms, the interactions and what an inflammatory-arthritis patient must know.
Read the guide →Best regenerative medicine treatments for osteoarthritis relief without surgery.
Non-surgical osteoarthritis treatments ranked on relief and durability: exercise, weight loss and semaglutide, topical NSAIDs, braces and aids, steroid injections, PRP, hyaluronic acid, duloxetine, stem-cell injections and exosomes — assembled into a twelve-week programme a pharmacist would prescribe.
Read the guide →Best regenerative medicine options for tendon and ligament injuries.
Tendon and ligament treatments ranked by tendon and by trial: progressive loading and eccentric exercise, shockwave, PRP (works for some tendons, fails for others), corticosteroid (worse at a year), needle tenotomy, surgery, stem-cell injections and exosomes — with the evidence stated for Achilles, patellar, elbow, rotator cuff and ligament injuries.
Read the guide →Best non-surgical regenerative medicine therapies for knee cartilage damage.
Non-surgical therapies for knee cartilage damage ranked on evidence: loading and quadriceps strengthening, weight loss and semaglutide, offloading, PRP, hyaluronic acid, steroid, cell injections, exosomes — with the MRI truth that no injection regrows cartilage, and when MACI or osteotomy is the real regenerative answer.
Read the guide →Best regenerative medicine solution to speed up sports injury recovery.
Sports injury recovery options ranked on return-to-play and re-injury evidence: early progressive loading, criteria-based rehabilitation, blood-flow restriction, PRP by injury (muscle, tendon, ligament), stem-cell injections, exosomes, peptides, hyperbaric oxygen — and what actually shortens the calendar without raising the re-injury rate.
Read the guide →Best evidence-based regenerative medicine therapy for chronic joint pain.
Chronic joint pain therapies ranked strictly on the trial evidence — named trials, populations and outcomes: exercise, weight loss and semaglutide, topical NSAIDs, MACI, corticosteroid, PRP, hyaluronic acid, duloxetine, cell injections and exosomes — with a pharmacist's verdict on what 'evidence-based regenerative' actually leaves.
Read the guide →The Longevity Brief
One evidence-graded email a week: what is new in longevity research, what is hype, and the one change actually worth making.
Free · one email a week · unsubscribe anytime.